
Zebra ZD421 Label Printers
Discover our full range of Zebra ZD421 label printers, engineered for advanced performance, flexible connectivity, and future-ready features. The ZD421 series builds on the legacy of Zebra’s popular desktop printers, offering more power and control for evolving business needs across retail, healthcare, manufacturing, and logistics.
Why Choose the Zebra ZD421?
The ZD421 delivers fast, high-quality label printing with enhanced features like a new, more intuitive user interface and greater processing capabilities. Available in direct thermal, thermal transfer, healthcare, and ribbon cartridge models, the ZD421 adapts to a wide variety of workflows, ensuring long-term reliability and ease of use.
Direct Thermal Models – Perfect for applications like shipping, receipts, and visitor passes. Requires no ribbon.
Thermal Transfer Models – Best for long-lasting labels that require durability in harsher environments.
Key Features:
- Print Width: Up to 4 inches (104mm)
- Resolution: 203 dpi or 300 dpi (model dependent)
- Print Speed: Up to 6 inches per second
- Connectivity: USB 2.0, USB Host, Bluetooth Low Energy (BLE); optional Ethernet, Wi-Fi, or Serial
- User-Friendly: 5 status icons and 3-button interface for easy operation
- Smart Features: Link-OS and Zebra’s Print DNA software for easier management and security
- Durability: Dual-wall construction for extra robustness
Applications:
- Shipping & Logistics Labels
- Retail Price, Shelf & Return Labels
- Healthcare Lab & Pharmacy Labels
- Product & Inventory Labels
- Patient Identification & Wristbands
Buy with Confidence
All Zebra ZD421 printers come with a 2-year standard warranty and are supported by our UK-based customer care team. Whether you need help deciding between a standard model or a healthcare-specific version, our experts are on hand to guide you to the right choice for your application.

SPEAK WITH BOB OR CHRIS ONE OF OUR TECHNICAL SPECIALISTS